The azole antifungal drugs
نویسندگان
چکیده
منابع مشابه
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.
Ketoconazole (KTZ) and other azole antifungal agents are known to have a variety of actions beyond the inhibition of sterol synthesis in fungi. These drugs share structural features with a series of novel heme oxygenase (HO) inhibitors designed in our laboratory. Accordingly, we hypothesized that therapeutically used azole-based antifungal drugs are effective HO inhibitors. Using gas chromatogr...
متن کاملClinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents.
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical setting for prophylaxis or treatment of systemic fungal infections. In this article, we review the pharmacokinetic interactions of these azole antifungal drugs with other coadministered agents. We describe these (2...
متن کاملAn Aptamer-Based Biosensor for the Azole Class of Antifungal Drugs
This technical report describes the development of an aptamer for sensing azole antifungal drugs during therapeutic drug monitoring. Modified synthetic evolution of ligands through exponential enrichment (SELEX) was used to discover a DNA aptamer recognizing azole class antifungal drugs. This aptamer undergoes a secondary structural change upon binding to its target molecule, as shown through f...
متن کاملImproved method for azole antifungal susceptibility testing.
A reproducible method is described for the determination of the MICs of ketoconazole, miconazole, fluconazole, and itraconazole with sharp endpoints when employed with either yeasts or molds. A semisolid medium is used with controlled pH and standardized inoculum. The time of reading results is a critical factor in the conduct of this test. The medium is simple to prepare and has a relatively l...
متن کاملCurrent and emerging azole antifungal agents.
Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B and ketoconazole. Despite these advances, serious fungal infections remain difficult to treat, and resistance to the available ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1987
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/20.1.1